Pre-eclampsia or eclampsia

DOID EFO MESH SNOMED PheWeb

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 O11, O14, O15.0, O15.1, O15.2

Hospital discharge: ICD-9 642[4-7]

Hospital discharge: ICD-8 6370[349]|63710|63799|66120

Cause of death: ICD-10 O11, O14, O15.0, O15.1, O15.2

Cause of death: ICD-9 642[4-7]

Cause of death: ICD-8 6370[349]|63710|63799|66120

Check pre-conditions None

Include endpoints None

Check conditions None

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Apply sex-specific rule

Sex only females

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O15_PRE_OR_ECLAMPSIA

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Pre-eclampsia or eclampsia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Pre-eclampsia superimposed on chronic hypertension

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4743	4743	-
Unadjusted prevalence (%)	1.82	3.23	-
Mean age at first event (years)	28.94	28.94	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.62 [0.42, 0.91]	1.5e-2	86
15 years	0.00	0.51 [0.32, 0.80]	3.5e-3	34
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

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Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Pre-eclampsia or eclampsia

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