Pregnancy hypertension

DOID EFO MESH SNOMED PheWeb

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16

Hospital discharge: ICD-9 642

Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799

Cause of death: ICD-10 O10, O11, O13, O14, O15, O16

Cause of death: ICD-9 642

Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule

Sex only females

O15_HYPTENSPREG

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Pregnancy hypertension based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9354	9354	-
Unadjusted prevalence (%)	3.60	6.37	-
Mean age at first event (years)	29.58	29.58	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.78 [0.61, 1.01]	5.6e-2	178
15 years	0.01	0.72 [0.53, 0.96]	2.8e-2	79
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

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Index endpoint: O15_HYPTENSPREG – Pregnancy hypertension
GWS hits: 8

Survival analyses between endpoints

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Plot

before Pregnancy hypertension
after Pregnancy hypertension

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Pregnancy hypertension

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