Hypertension complicating pregnancy, childbirth, and the puerperium

HELLP syndrome: HELLP syndrome is a life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia . If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also includemedications needed for the mother or baby, and blood transfusion for severe bleeding problems.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16
Hospital discharge: ICD-9 642
Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799
Cause of death: ICD-10 O10, O11, O13, O14, O15, O16
Cause of death: ICD-9 642
Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

Check pre-conditions None

Include endpoints None

Check conditions None

diagram bullet diagram downward connector

Apply sex-specific rule

Sex only females
diagram downward connector I9_HYPTENSPREG

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Hypertension complicating pregnancy, childbirth, and the puerperium based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 9354 9354 -
Unadjusted prevalence (%) 3.60 6.37 -
Mean age at first event (years) 29.58 29.58 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.65 [0.50, 0.84] 1.3e-3 178
15 years 0.00 0.59 [0.43, 0.80] 6.7e-4 79
5 years - - - -
1 year - - - -

Correlations

Index endpoint: I9_HYPTENSPREG – Hypertension complicating pregnancy, childbirth, and the puerperium
GWS hits: 8

Survival analyses between endpoints

Plot

before Hypertension complicating pregnancy, childbirth, and the puerperium
after Hypertension complicating pregnancy, childbirth, and the puerperium

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertension complicating pregnancy, childbirth, and the puerperium