Type 1 diabetes, strict definition, subgroup 1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

Filter registries None

diagram bullet diagram downward connector

Check pre-conditions

Pre-conditions EVENT_AGE<40
diagram bullet diagram downward connector

Include endpoints

diagram bullet diagram downward connector

Check conditions

not E4_DM2
and not PANCREATITIS
and KELA_DIAB_INSUL
and INSULIN_SHORTFAST
and INSULIN_INTER_AND_LONG

Apply sex-specific rule None

diagram downward connector T1D_STRICT1

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2992 1483 1509
Unadjusted prevalence (%) 1.15 1.01 1.33
Mean age at first event (years) 17.78 17.17 18.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.08 [1.80, 5.26] 3.8e-5 59
15 years 0.02 2.99 [1.70, 5.25] 1.4e-4 32
5 years - - - -
1 year - - - -

Correlations

Index endpoint: T1D_STRICT1 – Type 1 diabetes, strict definition, subgroup 1
GWS hits: 23

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict definition, subgroup 1
after Type 1 diabetes, strict definition, subgroup 1

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes, strict definition, subgroup 1