Type 1 diabetes

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E10
Cause of death: ICD-10 E10

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_DM1

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) juvenilis

Similar endpoints

List of similar endpoints to Type 1 diabetes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 7608 3552 4056
Unadjusted prevalence (%) 2.93 2.42 3.59
Mean age at first event (years) 31.53 29.12 33.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.72 [4.67, 7.01] 1.4e-63 984
15 years 0.04 6.03 [5.05, 7.19] 6.1e-88 774
5 years 0.01 7.87 [6.51, 9.52] <1e-100 314
1 year 0.00 10.89 [8.33, 14.23] 3.6e-68 89

Correlations

Index endpoint: E4_DM1 – Type 1 diabetes
GWS hits: 30

Survival analyses between endpoints

Plot

before Type 1 diabetes
after Type 1 diabetes

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