Type 1 diabetes with neurological complications

DOID EFO MESH SNOMED PheWeb

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

↥

FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0

Hospital discharge: ICD-9 2505B

Cause of death: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0

Cause of death: ICD-9 2505B

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

E4_DM1NEU

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Similar endpoints

↥

List of similar endpoints to Type 1 diabetes with neurological complications based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	740	350	390
Unadjusted prevalence (%)	0.28	0.24	0.34
Mean age at first event (years)	44.71	42.78	46.44

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	4.93 [2.75, 8.82]	7.8e-8	135
15 years	0.04	5.96 [3.66, 9.71]	7.7e-13	111
5 years	0.01	9.97 [6.20, 16.04]	2.3e-21	50
1 year	0.00	12.34 [6.25, 24.39]	4.8e-13	12

Correlations

↥

Index endpoint: E4_DM1NEU – Type 1 diabetes with neurological complications
GWS hits: 9

Survival analyses between endpoints

↥

Plot

before Type 1 diabetes with neurological complications
after Type 1 diabetes with neurological complications

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Type 1 diabetes with neurological complications

↥