Type 1 diabetes with ketoacidosis

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E10.1
Hospital discharge: ICD-9 2501B
Cause of death: ICD-10 E10.1
Cause of death: ICD-9 2501B

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_DM1KETO

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10

Summary Statistics

Key figures

All Female Male
Number of individuals 1628 801 827
Unadjusted prevalence (%) 0.63 0.55 0.73
Mean age at first event (years) 24.88 24.24 25.50


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.15 11.43 [2.98, 43.77] 3.8e-4 166
15 years 0.10 16.37 [5.31, 50.49] 1.2e-6 134
5 years 0.03 31.19 [13.83, 70.31] 1.1e-16 65
1 year - - - -


Index endpoint: E4_DM1KETO – Type 1 diabetes with ketoacidosis
GWS hits: 15

Survival analyses between endpoints


before Type 1 diabetes with ketoacidosis
after Type 1 diabetes with ketoacidosis

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Drugs most likely to be purchased after Type 1 diabetes with ketoacidosis