Diabetic ketoacidosis

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Hospital discharge: ICD-9 2500
Hospital discharge: excluded ICD-9 E121
Cause of death: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Cause of death: ICD-9 2500
Cause of death: excluded ICD-9 E121

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector DM_KETOACIDOSIS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 5703 2657 3046
Unadjusted prevalence (%) 2.19 1.81 2.69
Mean age at first event (years) 31.91 29.69 33.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.00 [3.21, 4.99] 1.0e-34 1266
15 years 0.03 4.24 [3.61, 4.98] 1.0e-69 974
5 years - - - -
1 year - - - -

Correlations

Index endpoint: DM_KETOACIDOSIS – Diabetic ketoacidosis
GWS hits: 21

Survival analyses between endpoints

Plot

before Diabetic ketoacidosis
after Diabetic ketoacidosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic ketoacidosis