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Type 1 diabetes with ophthalmic complications

DOIDEFOMESHSNOMED PheWeb

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Hospital discharge: ICD-9 2504B
Cause of death: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Cause of death: ICD-9 2504B

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_DM1OPTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 3668 1909 1759
Unadjusted prevalence (%) 1.41 1.30 1.56
Mean age at first event (years) 36.54 35.27 37.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.80 [3.23, 10.43] 4.3e-9 333
15 years 0.05 7.19 [4.57, 11.30] 1.2e-17 268
5 years 0.01 8.26 [5.41, 12.63] 1.6e-22 88
1 year 0.00 9.22 [5.13, 16.55] 1.0e-13 18

Correlations

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Index endpoint: E4_DM1OPTH – Type 1 diabetes with ophthalmic complications
GWS hits: 27

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ophthalmic complications
after Type 1 diabetes with ophthalmic complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with ophthalmic complications

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