Ulcerative colitis

DOID EFO MESH SNOMED PheWeb

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K51

Hospital discharge: ICD-9 556

Hospital discharge: ICD-8 5631|569

Hospital discharge: excluded ICD-9 5564A

Cause of death: ICD-10 K51

Cause of death: ICD-9 556

Cause of death: ICD-8 5631|569

Cause of death: excluded ICD-9 5564A

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

K11_ULCER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K50-K52

Name in latin Colitis ulcerosa

Similar endpoints

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List of similar endpoints to Ulcerative colitis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5348	2836	2512
Unadjusted prevalence (%)	2.06	1.93	2.22
Mean age at first event (years)	42.19	40.61	43.96

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.90 [1.45, 2.49]	2.8e-6	372
15 years	0.01	2.06 [1.63, 2.61]	1.6e-9	275
5 years	0.00	3.33 [2.57, 4.30]	4.7e-20	107
1 year	0.00	5.55 [3.73, 8.27]	2.9e-17	32

Correlations

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Index endpoint: K11_ULCER – Ulcerative colitis
GWS hits: 12

Survival analyses between endpoints

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Plot

before Ulcerative colitis
after Ulcerative colitis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Ulcerative colitis

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