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Alzheimer’s disease, wide definition

DOIDEFOMESHSNOMED PheWeb

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data
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Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 F00*, G30
Hospital discharge: ICD-9 3310
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*, G30
Cause of death: ICD-9 3310
Cause of death: ICD-8 29010
KELA reimbursements: KELA codes 307
KELA reimbursements: ICD-10 F00*, G30
Medicine purchases: ATC N06D
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

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Include endpoints

Check conditions None

Apply sex-specific rule None

diagram downward connector G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 7326 3577 3749
Unadjusted prevalence (%) 2.82 2.43 3.32
Mean age at first event (years) 78.04 78.60 77.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.17 10.80 [9.45, 12.34] <1e-100 2930
15 years 0.09 10.77 [9.42, 12.31] <1e-100 2918
5 years 0.01 10.58 [9.46, 11.83] <1e-100 1968
1 year 0.00 9.52 [8.15, 11.13] <1e-100 468

Correlations

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Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 3

Survival analyses between endpoints

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Plot

before Alzheimer’s disease, wide definition
after Alzheimer’s disease, wide definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer’s disease, wide definition

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