Type 2 diabetes, definitions combined

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

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Check conditions

not E4_DM1

Apply sex-specific rule None

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Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 37022 16842 20180
Unadjusted prevalence (%) 14.24 11.46 17.85
Mean age at first event (years) 60.06 59.27 60.72

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.55 [2.30, 2.84] 1.2e-67 5683
15 years 0.02 2.88 [2.64, 3.16] <1e-100 4847
5 years 0.00 3.95 [3.62, 4.32] <1e-100 1903
1 year 0.00 5.42 [4.66, 6.31] <1e-100 484

Correlations

Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 107

Survival analyses between endpoints

Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

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Drugs most likely to be purchased after Type 2 diabetes, definitions combined