Type 2 diabetes

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E11
Cause of death: ICD-10 E11
Medicine purchases: ATC A10B
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_DM2

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Similar endpoints

List of similar endpoints to Type 2 diabetes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 41235 18715 22520
Unadjusted prevalence (%) 15.86 12.74 19.92
Mean age at first event (years) 58.43 57.57 59.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.81 [2.54, 3.10] 3.8e-91 6528
15 years 0.02 3.14 [2.89, 3.42] <1e-100 5469
5 years 0.00 4.19 [3.85, 4.56] <1e-100 2068
1 year 0.00 5.50 [4.74, 6.39] <1e-100 514

Correlations

Index endpoint: E4_DM2 – Type 2 diabetes
GWS hits: 105

Survival analyses between endpoints

Plot

before Type 2 diabetes
after Type 2 diabetes

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