Type 1 diabetes, strict definition

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

diagram bullet diagram downward connector

Include endpoints

diagram bullet diagram downward connector

Check conditions

not E4_DM2

Apply sex-specific rule None

diagram downward connector T1D_STRICT

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 3242 1612 1630
Unadjusted prevalence (%) 1.25 1.10 1.44
Mean age at first event (years) 16.26 15.66 16.86

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.47 [2.67, 7.47] 1.1e-8 97
15 years 0.03 5.36 [3.06, 9.38] 4.2e-9 66
5 years 0.01 5.12 [2.30, 11.39] 6.2e-5 12
1 year - - - -

Correlations

Index endpoint: T1D_STRICT – Type 1 diabetes, strict definition
GWS hits: 23

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict definition
after Type 1 diabetes, strict definition

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Drugs most likely to be purchased after Type 1 diabetes, strict definition